Socio-economic issues. Driver shortages. Political challenges. Rising materials costs. Limited capacity. Natural disasters. Loss of a supplier, customer, trading partner. Labor shortages. Cargo theft. Poor quality materials. Mergers & Acquisitions.The supply chain is subject to many activities that create risk within the supply chain, disrupting everything from production, manufacturing or distribution to losing a transportation mode, all of which can hurt your bottom line and make customers unhappy.